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Myeloid-specific GPX4-haploinsufficient mice develop a lupus-like disease spontaneously, but complete GPX4 ablation in neutrophils results in severe neutropenia without inducing a lupus-like disease

Synthesis of l (or d)-lactyl N -hydroxysuccinimide ester l-lactic acid (0.9 g, 10 mmol) and N -hydroxysuccinimide (1.38 g, 12 mmol) were dissolved in dichloromethane and stirred at room temperature for 0.5 h

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For one, the frequent clinic visits for injections can be inconvenient and sometimes painful for patients, particularly for those who have an aversion to needles

Downstream events of PI3KC3-C1 activity result in the formation of LC3-PE, an autophagic cargo tether, formed by the conjugation of LC3-I (microtubule-associated protein 1A/1B-light chain 3) protein and the PE (phosphatidylethanolamine) lipid [40]