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These programs actively suppress immune surveillance by competing with effector lymphocytes for glucose and amino acids, secreting lactate to acidify the TME, and generating adenosine via CD39/CD73 to blunt T cell and NK cell activity

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Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications

Despite the complexity of the underlying mechanisms, there are intriguing reports that CB receptor agonists have improved AD symptoms

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However, the range of GT substrates has expanded considerably, now including a range of GSH conjugates, leukotriene C4 (LTC4), S -nitroso-GSH and GSH adducts of xenobiotics, suggesting diverse roles for GT