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Ipamorelin is another synthetic peptide that may interact with pituitary cells, although it appears to do so by triggering a different receptor called the growth hormone secretagogue (GHS) receptor

In this example and in type 1 diabetes, it has been discussed whether the normalization of glucose metabolism following rhIGF-I therapy is most importantly associated with insulin-like effects of IGF-I on glucose uptake in muscle or suppression of GH hypersecretion

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