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Strengthening this assumption, studies have reported that mammalian mitochondrial RNAse P does not require the catalytic RNA component for catalysis (Rossmanith et al., 1995

Deficient muscle carnitine transport in primary carnitine deficiency

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2b,c) and the carnitine synthesis inhibitor mildronate, we validated this observation in both CCNE1-driven cell lines using both olaparib and cisplatin (Fig

The management of hyperammonemia includes 1) identification of precipitating factors and cerebral edema presence, 2) a decrease in ammonia production by reducing protein intake and reversing catabolism, and 3) ammonia removal with pharmacologic treatment and, in the most severe cases, with extracorporeal therapies