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The challenges in preclinical studies and clinical trials, and the implications of these targeted pharmacological treatments for other ASDs and related neurodevelopmental disorders are also discussed

100 The brain and spinal cord are protected by highly selective barriers that, while essential for maintaining neural homeostasis and protecting against pathogens, limit the penetration of potentially beneficial therapeutic compounds

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doi: 10.1371/journal.pone.0082485 141 SalehiH.BahramnejadB.MajdiM