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Funding This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

MTT solution was added to each well, followed by incubation for 1 h at a final concentration of 5 mg/mL in 5% CO 2 at 37 C

These nutraceuticals have some mechanisms of action in common, including the inhibition of ACE, the enhancement of NO-mediated vasodilation, interactions with ion channels including the blocking of calcium channels and opening of potassium channels with consequent membrane hyperpolarization, anti-inflammatory effects with reductions in synthesis and release of pro-inflammatory cytokines, and enhancement of endogenous antioxidant actions exerted by different enzymes, such as SOD, GPx, and GSTP

M., Singh S

Most gastrointestinal events were classified as mild to moderate, and the majority were transient, resolving within the first several weeks of treatment or after dose stabilization