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Finally, a promising line of research proposes a multifactorial approach, by developing a predictive algorithm based on familial/genetic factors, environmental adversity, early behavioral phenotype, biological markers [inflammatory cytokines, BDNF, markers of oxidative stress, and hypothalamicpituitaryadrenal (HPA) disturbance], and imaging data (7982)

Several reports have also documented a dose- and duration-dependent association between chronic opioid treatment and new-onset depression [106]

Stress as a cause is common, we as patients have noted

Zhang, B., Zhang, Y., Xing, X., & Wang, S

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