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This is a common practice with many bioactive compounds to prevent the body from downregulating its own natural repair mechanisms or becoming desensitized

10.2174/156652306776359487 102 TuY.SongE.WangZ.JiN.ZhuL.WangK.et al (2021)

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and v) the DN + si-Nrf2 + DAPA group (si-Nrf2 + DAPA group), which received tail vein injections of si-Nrf2 (5 nmol/20 g) every 3 days and daily oral gavage of DAPA (10 mg/kg/day) for 8 weeks