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The aging process is marked by a gradual yet progressive decline in the functional capacity of multiple organs, impairing their ability to sustain baseline tissue homeostasis and adequately respond to physiological demands under stress ( 3.5 Chemotherapy-induced renal injury 3.5.1 Cisplatin-induced nephrotoxicity Cisplatin (CP) is a prominent chemotherapeutic agent utilized in the treatment of solid tumors (Yao et al., 2007)

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510 Antioxidant enzymes are key biomarkers of oxidative stress and are extensively studied as ROS-related indicators in numerous cancer clinical trials

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450 Notably, inhibiting histone lactylation can significantly increase the sensitivity of malignant tumors to bevacizumab, a common first- and second-line antiangiogenic drug in CRC