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Niacinamide: A form of vitamin B3 that can help to improve the skins texture, reduce the appearance of pores, and brighten the complexion

In the catalytic cycle of GPX4, the -SeH (the main active group of GPX4) is oxidized by the PLOOH to selenic acid (-SeOH), while G-SH can reduce -SeOH and further activates GPX4, releasing GS-SG to prevent GPX4 from being inactivated (Ingold et al., 2018)

This method is especially beneficial for individuals dealing with chronic illness, inflammation, or toxin buildup, as it allows for rapid cellular uptake

This strategy is the basis for many anticancer therapeutics, including chemotherapeutics, radiotherapies, and most small-molecule inhibitor-based therapies, which impair tumor metabolism and induce excessive ROS accumulation, inducing cell toxicity and death