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The antioxidative function of alpha-ketoglutarate and its applications

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and Rogers, M.J

Cimetidine (Tagamet), a histamine H2 antagonist used to treat acid reflux and heartburn, was found in one small randomized controlled trial to improve pain and sleep disruption in IC/BPS sufferers

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These included central kinases such as PAK1/2, the Wnt signaling pathway component Catenin beta1 (CTNNB1) as well as the plasma membrane effectors such as the small GTPase RAB7A, the latter regulating the expression of ACE2 on the cell surface in dependence on its phosphorylation status (Daniloski et al , 2021)