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10.21776/ub.jitek.2019.014.02.3 159 SahebkarA

The primary signs GHK-Cu has degraded include visible discoloration (shift from light blue to brown or colorless), precipitation or clumping after reconstitution, pH drift outside the 5.56.5 range, and loss of copper ion coordination indicated by EDTA test failure

Zanotelli, M

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This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1, and TNF-, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-)