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Due to the half-life of the dsRNA, the effectiveness of RNAi gradually weakens with an increasing length of time after treatment, so there may be a discrepancy in the life events (such as laying and hatching of eggs) after engorgement of ticks

Hedstrom M Article: BMC GERIATRICS

What is the Fibula

In the case of severe vitamin B12 deficiency, consider discussing with your physician whether vitamin B12 injections can be an appropriate option

The standard-of-care for symptomatic patients usually includes an initial phase (around 2-6 months) of copper chelation with agents, such as penicillamine or trientine (triethylenetetramine), followed by lifelong maintenance therapy with penicillamine and/or trientine and/or zinc salts (107)

2014 Jun;35(6):469-75