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one suggested that an intronic marker of CYP46 interacts with age and apoE genotype (Johansson et al., 2004)

T3 also increases liver lysosomal activity by upregulating lysosomal genes and increasing lysosome-associated membrane protein stability, which constitutes ~50% of all proteins found in lysosome membranes

Store unreconstituted vials as directed on the label and protect from heat and light

Because some medications inhibit, block, or are metabolized by alcohol dehydrogenase and other liver detoxification pathways, excess alcohol can decrease clearance of these drugs, increasing the risk of adverse side effects and toxic overdose

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The singler package (version 1.6.2) was then automatically annotated, along with manual querying of the Human Cell Landscape (HCL) database ( for the purpose of cell clustering 48,52