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Results Disruption of the glucagon receptor significantly alters both gene expression and the interactive network of cells To comprehensively examine the functional and physiological changes in cells following GCGR blockade, we conducted single-cell RNA sequencing (scRNA-seq) on islets isolated from 1214-week-old male wild-type (WT) and GCGR-knockout (KO) mice (Fig

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This preservation of lean mass helps maintain metabolic rate during fat loss phases and creates more favorable body composition outcomes

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However, severe or prolonged deficiency may cause permanent follicle damage