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Clinical wound healing studies involving direct application to open wounds have shown good tolerability without significant adverse effects, and wound healing outcomes are generally improved rather than impaired

171,172,173 Less prominent reactive morphotypes represented by polarised cells, which extend their processes toward the lesion area, are positioned more distantly, whereas healthy looking neuroglia demarcate the undamaged tissue

358 In addition, ferroptosis caused by sulfasalazine has a dual role

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Their integrative use alongside conventional therapies represents a promising approach for more holistic and personalized management of PCOS ( 6 Therapeutic potential and mechanistic insights Apigenin and ellagic acid are naturally occurring polyphenols with significant therapeutic potential in polycystic ovary syndrome (PCOS) ( Table 3 )