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Mechanistic studies established that the compounds decrease intracellular levels of the fosB cofactor bacillithiol through a thiol-disulfide exchange reaction

We found that RES or NAC significantly restored cell morphology (Figure 6A), increased cell viability (Figure 6B), and reduced apoptosis caused by OA treatment (Figure 6C), but did not restore proliferation at a series of concentrations (Figure 6D

Cattani-Cavalieri I, da Maia VH, Moraes JA, Brito-Gitirana L, Romana-Souza B, Schmidt M, et al

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