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Both lactate and its agonist, DHBA, induced a biphasic modulation in neuronal excitability, inducing reduced excitability at lower concentrations (lactate at 5 mM and DHBA at 0.56 mM), while higher concentrations (lactate at 30 mM and DHBA at 3.1 mM) increased firing frequencies

(169) showed diabetic animal models administered berberine activates the Nrf2 pathway and decreases OxS

doi: 10.1186/s11658-021-00271-y 41 WuYKramHGemptJLiesche-StarneckerFWuWSchlegelJ

A competition of GPxs for selenium incorporation Koyama with coworkers 22 have found that reduced serum level of selenoprotein P was associated with a higher risk of stroke