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The p K a of the histidine imidazole group is 6.5, and thus histidine behaves as hydrophobic residue at neutral pH, whereas it is protonated and behaves as a basic peptide in the slightly acidic endosomal milieu

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Gstraunthaler G, Holcomb T, Feifel E, Liu W, Spitaler N, Curthoys NP

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Each of these genes provides the instructions for a specific enzyme

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Cocaine induces cardiac dysrhythmias such as sinus tachycardia, wide complex supraventricular tachycardia, atrial fibrillation, and ventricular tachycardia