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An additional 5-mm margin is taken from around the positive area, and the tissue is again subjected to gross examination according to protocol and the margins are evaluated by en face sectioning (Reprinted from Bosbous MW, Dzwierzynski WW, Neuburg M

The TNM staging system was updated by the American Joint Committee on Cancer in 2017 with the 8th edition of the Cancer Staging Manual, excluding the possibility of having stage I and II disease