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doi: 10.1016/j.expneurol.2006.08.008

Most of the research in these areas comes from in vitro or animal studies, and there are no high-quality clinical trials consistently showing cosmetic or lifespan-extending effects in people.33 34 66 A few small studies suggest topical ALA may offer modest benefits for skin appearance, but these findings are early and so far dont apply to oral supplementation.35 Youre using ALA for weight loss You take certain medications ALA can interact with several medications.39 These include drugs for diabetes (like insulin or metformin), thyroid medications (like levothyroxine), and certain chemotherapy agents such as alkylating agents and antitumor antibiotics

Note that the USDA choline database only includes 630 foods, so one's real intake is certainly higher than what nutrition software indicates -- but don't let this make you overconfident of adequacy

Bear MF, Connors BW, and Paradisio MA

The final, crucial step in the detoxification process is ensuring that mobilized heavy metals are actually expelled from the body and not simply reabsorbed in the digestive tract

Genotyping Genomic DNA was isolated from blood samples (Puregene Systems, Gentra)