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358 Similarly, gene therapy employing adeno-associated virus (AAV) 9 vectors to overexpress telomerase reverse transcriptase (TERT) has been demonstrated to alleviate age-related telomere damage and delay senescence in mouse models of cancer resistance

High expression of IL-23 has been observed in psoriatic skin lesions, and experimental models have demonstrated that IL-23 injection can induce epidermal hyperplasia through keratinocyte proliferation in mice (56)

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In this respect, the new findings about the intracellular redox cycle of B 12 (see Section 2.2) and its possible action as a cellular antioxidant (see Section 3.3) may provide a better explanation for the neurological symptoms of B 12 deficiency than its role as cofactor of the two enzymes [41,42]

Obesity small increases in weight place dramatically increased stress on the kneecap and extensor mechanism

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