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In PD cell models, GAPDH co-localizes with -syn in Lewy bodies, accompanied by reduced GAPDH activity [70]

This work has been funded by the European UnionNextGenerationEUunder the Italian Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041VITALITYCUP [H33C22000430006]

Our findings, mirror the differences of Stage 2 or Stage 3 siblings when independently measured and show dramatic and statistically significant reductions of GPx3 in the most severely affect children ( p = 2.47 10 8 , Paired t-test) again with non-overlapping 95% confidence intervals (95% CI Unaffected Stage 2/3 [1.7 ug/ml, 2.1 ug/ml], 95% CI Konzo Stage 2/3 [0.98 ug/ml, 1.3 ug/ml]) (Fig

In contrast, HIIT offers beneficial acute immune activation, enhancing NK cell cytotoxicity and modulating inflammatory markers, though its long-term effects on immune regulation are still under investigation

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& Sopory, S