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*Correspondence: Binghu Fang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Recently, Amaretti et

Heavy drinking depletes hepatic glutathione by 5080% within hours, creating a bottleneck where acetaldehyde accumulates faster than ALDH2 can clear it

For instance, Chen et al

These compounds include pyruvate, which can be converted into acetyl-CoA and enter the tricarboxylic acid (TCA) cycle or be used for fatty acid synthesis, and -ketoglutarate, a precursor of glutamate and an intermediate of the TCA cycle

Science, 2021