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For the antioxidative enzymes system and chaperones, the expression level of copper/zinc superoxide dismutase isoform 4 , glutathione peroxidase , glutathione S-transferase , peroxiredoxin , peroxiredoxin 6 , and dual oxidase 2 in stage C or stage D significantly higher than that of stage E or stage AB

Drug solutions, typically 5 mg/ml in HPLC-grade water (except for Dihexa, prepared in DMSO), were added to rat serum, and the mixture was incubated at 37C

The same procedures were applied to the control group but this time saline was used

Therefore, we postulated in this study that oxidative stress stimulated in DCM induced the activation of NLRP3 and the ensuing pyroptosis, thereby governing the death of cardiomyocytes and activation of fibroblasts

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doi: 10.1152/ajpgi.00324.2001