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[DOI] [PubMed] [Google Scholar] 123.Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim SJ, Zhang L, Koob GF, Gao B

Bleeding disorders, vascular issues, or difficulty accessing veins may complicate IV therapy

Oxidative stress has been identified as a major cause of BBB damage in the subacute phase of blast TBI, and subsequent matrix metalloproteinase (MMP) activation can also lead to oxidative stress-mediated loss of BBB integrity (127)

For survival experiments, SCID mice were monitored daily for the development of clinical signs of disease and examined in case any abnormality of behavior was observed

Certain medications, including beta-blockers, non-steroidal anti-inflammatory drugs (NSAIDs), and some antidepressants, may interfere with melatonin synthesis or secretion

Recent approaches integrating chemogenetic modulation (e.g., clozapine-N-oxide induction) with fluorescence-activated cell sorting and transcriptomic profiling have enabled detailed mapping of activity-dependent gene networks in endothelial cells, key BBB transporters such as P-glycoprotein show rhythmic expression coordinated with core clock genes, generating time windows that favor CNS drug penetration (54, 55)