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This peptide, consisting of 28 amino acids, is widely distributed in the nervous system and acts as a neurotransmitter, neuromodulator, and vasodilator

USA 83 , 82068210 (1986)

However, the centrifugation step presents a significant challenge

They have become essential components for optogenetic applications, where they can be fused to different output domains to provide light control of various cellular functions 1