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The ability of G/D-CuP to scavenge reactive oxygen species (ROS) was evaluated by conducting Fenton-like reactions where hydrogen peroxide (H 2 O 2 ) generates reactive hydroxyl radicals (OH) with the help of metal catalysts, leading to significant oxidative harm 65

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These platforms improve water solubility and cell permeability, optimize the pharmacokinetic characteristics of PROTAC, and promote selective localization in tumor tissue through passive or active targeting strategies, thus significantly enhancing treatment selectivity and treatment window [41,42,43,44]

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J Biol Chem 280:2557125579 Koehler RC, Roman RJ, Harder DR (2009) Astrocytes and the regulation of cerebral blood flow