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1 Deficiency is often due to a lack of B12 foods in the diet, absorption issues, and/or genetic mutations that affect uptake

Figure 4 Macrophages are the key mediators by which monoclonal antibodies to play a therapeutic role, and antibodies targeting CD38 will also affect macrophage function ( Summary and Prospects CD38 has dual functions, acting as an extracellular enzyme and a surface receptor

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[16] Transport-mediated absorption and tissue delivery is a complex process involving three transport proteins: haptocorrin (HC), intrinsic factor (IF) and transcobalamin II (TC2), and respective membrane receptor proteins (Figure)