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Importantly, as the chief brain source of APOE, astrocytes, especially those expressing the APOE4 allele, promote A aggregation, tau pathologies, BBB breakdown, and cerebrovascular dysfunctions (Wang M

Since polygenic risk score calculation requires large GWAS datasets, some neurodegenerative disorders such as frontotemporal dementia (FTD) or ALS currently lack well-established standards like those available for AD or PD (Lambert et al., 2023)

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