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Many people seeking neuromodulator treatment to address lines and wrinkles are in their late twenties to early sixties

Serine racemase and the serine shuttle between neurons and astrocytes

Embodiment 57 of this disclosure are compounds of Formula I, I-a, or I-b, or Embodiments 1-56, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 6 is F, Cl, CHF 2 , CH 3 , OCHF 2 , OCF 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCF 2 CHF 2 , OCH 2 CHF 2 , C(CH 3 )F 2 , CH 2 CN, C(O)NHC(CH 3 ) 3 , OCH 3 CN, CH 2 CH 3 , CN, C(CH 3 ) 2 NH 2 , S(O 2 )CH 3 , S(O 2 )NHCH 2 CH 3 , OCD 2 CD 3 , pyrazolidine, cyclopropyl, cyclobutyl, or O-cyclopropyl, and wherein the cyclopropyl or cyclobutyl is additionally optionally substituted with Embodiment 58 of this disclosure are compounds of Formula I, I-a, or I-b, or Embodiments 1-57, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 6 is CH 3 , OCH 2 CH 3 , C(O)NHC(CH 3 ) 3 , C(CH 3 ) 2 NH 2 , S(O 2 )CH 3 , S(O 2 )NHCH 2 CH 3 , OCD 2 CD 3 , pyrazolidine, or O-cyclopropyl, and wherein the cyclopropyl is additionally optionally substituted with one to three halogen atoms

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This anti-inflammatory effect may also alleviate symptoms of problematic skin conditions like the aforementioned rosacea, which causes redness, irritation, and inflammation of the skin

Activated mast cells can trigger microglial activation via the release of histamine, prostaglandins, and protease-activated receptor ligands (Zhang et al., 2016)