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doi: 10.1016/j.jff.2019.02.015

Additionally, rhamnetin disrupts the cleavage of the Notch-1 receptor by gamma-secretase, preventing the release of the Notch intracellular domain (NICD)

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Comparator (C), gene deletion and wild type

Dysbiosis-induced increased intestinal permeability allows the translocation of bacterial endotoxins, notably LPS, into the systemic circulation, triggering inflammatory cascades that compromise thyroid tissue integrity and hormone synthesis