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Fine lines and wrinkles develop due to a combination of: Collagen and elastin loss with age Repeated facial expressions (smiling, frowning, squinting) Sun exposure (photoaging) Dehydration and impaired skin barrier Lifestyle factors (stress, sleep, nutrition) Over time, these lead to visible changes in skin texture, elasticity, and volume

In: Demmig-Adams B, Adams W, Mattoo A (eds) Photoprotection, photoinhibition, gene regulation, and environment

Wyckelsma VL, Levinger I, McKenna MJ, Formosa LE, Ryan MT, Petersen AC et al (2017) Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training: high-intensity training in elderly humans

To confirm whether this change is cancer-cell-specific, we tested human mesenchymal stromal cells (hMSCs) representative of cancer stroma 28

MNX1-AS1 promotes phase separation of IGF2BP1 to drive c-Myc-mediated cell-cycle progression and proliferation in lung cancer

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