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The body floods the area with inflammatory cytokines in an attempt to deal with the injury, but this often makes things worse, creating a vicious cycle of swelling, more pressure, and more pain

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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (71)