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To verify the role of GSH in activating long-distance plant defense signaling events, we wounded leaf 1 of pad2-1 and Col-0, and then measured the accumulation of wound-induced plant defensive hormonal molecules in leaf 6, considering that leaf n shares direct vascular connections with leaves n 5 and n 8 while leaves n 3 may represent contact parastichies formed by proximal but unconnected vasculature in adult Arabidopsis rosettes 7,25

It was discovered 130 years ago in baker's yeast (Saccharomyces cerevisiae)

Crosstalk between thiol antioxidant systems is further reinforced by redox-sensitive transcription factors, including NFE2L2 and TP53 123

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