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Splicing factor SF3b as a target of the antitumor natural product pladienolide

This state acts as a transient intermediate where the redox reaction occurs leading to ROS degeneration 10

Release of pro-inflammatory mediators by microglia, the main effector cells of inflammation within the central nervous system (CNS), could be sufficient to cause AD pathology independently of other pathological events, such as deposition of the amyloid b protein (Ab) and neurofibrillary tangles (NFT) [4,5]