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The resulting S- substituted cysteinylglycines are cleaved by dipeptidase (Reaction 6A) to yield the corresponding S- substituted cysteines, which may undergo N-acetylation (Reaction 8) or an additional transpeptidation reaction to form the corresponding -glutamyl derivative (Reaction 3A)

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KG, 3 Department of Medical Sciences, Division of Gastroenterology, University of Turin, 4 The Texas Liver Institute, University of Texas Health San Antonio, and Arizona Liver Health, 5 Boehringer Ingelheim International GmbH, 6 Department of Internal Medicine II, Saarland University Medical Center, 7 National Institute for Health Research Biomedical Research Centre, University Hospital Birmingham, 8 Faculty of Medical Sciences, Newcastle University, 9 Covenant Metabolic Specialists, LLC, 10 Texas Liver Institute, University of Texas Health San Antonio, 11 The Institute of Cardiometabolism and Nutrition, Sorbonne Universit, Hpital PitiSalptrire, 12 Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 13 Boehringer Ingelheim Pharmaceuticals, Inc., 14 Virginia Commonwealth University Background: We evaluated non-invasive liver biomarkers from a phase II trial of survodutide, a novel glucagon receptor/glucagon-like peptide-1 receptor dual agonist for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis

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