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Independent of the species that triggers aggregation, it is generally accepted that a gain-of-function toxicity of the expanded ATXN3 protein contributes highly to SCA3 pathology

For these reasons, a study on the pharmacokinetic and pharmacodynamic effects of the combination is needed 154

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112 Finally, the BPC 157-NO-system-relation includes complex healing failure, proved by the fistulas healing, 82 , 84 - 86 or particular anastomoses healing 88 or vessel occlusion 101 , 113 or cytostatic agents application (i.e., doxorubicin, cyclophosphamide)

These results implied that there was a significant chemodynamic/photothermal synergistic effect of FeS@SRB + NIR, which played an important role in antitumor therapy