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Knockout of sestrins, or at least impairment of their leucine-binding ability, could make mTORC1 activity insensitive to leucine stimulation

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This clearly signifies that the trend of reduced distance between normal M1 and modified M2 holds true for these select pathways

2012;8(6):e1002777

[DOI] [PubMed] [Google Scholar] 44.Kang E.A., Han Y.-M., An J.M., Park Y.J., Sikiric P., Kim D.H., Kwon K.A., Kim Y.J., Yang D., Tchah H., et al