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Cytokines The relatively spectacular improvement seen clinically with anti-VEGF drugs emphasises the importance of this cytokine as a final common pathway of damage to the retina and its vasculature

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Additionally, HA formulations are advancing in ophthalmology for corneal healing and intraocular surgery, in dentistry for periodontitis therapy and bone regeneration, and in dermatology and cosmetics for skin rejuvenation, hydration, and anti-aging interventions

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demonstrated that TGF-/Smad4 signaling upregulates miR-155, which in turn promotes TGF--induced epithelialmesenchymal transition (EMT), tight junction dissolution, and cell migration (74)

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Lima SGM, Freire MCLC, Oliveira VDS, Solisio C, Converti A, de Lima AN (2021) Astaxanthin delivery systems for skin application: a review

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Interacting with Other Antioxidants: While GPx1 deletion increases damage without affecting longevity directly, it highlights compensatory mechanisms

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Blood 139, 24602470

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