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Due to the presumed link between iron deficiency or altered iron metabolism in the brain and RLS (Conner 2008), one of the more common alternative treatments for RLS is iron supplementation (Trotti 2009)

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75,169,170 Reactive microglia first position themselves between the infiltrating lymphocytes and newly proliferating reactive astrocytes that will form the perilesional border of astrocytes

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Ferroptosis as a therapeutic target in CVD Targeting the core pathological drivers of ferroptosisincluding dysregulated iron metabolism, uncontrolled lipid peroxidation, impairment of the GPX4 antioxidant axis, and additional regulatory pathways such as FSP1CoQ 10 , GCH1BH4, and DHODHrepresents a promising strategy to suppress ferroptosis in cardiovascular disease