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European Commission 6511/VI/99-final

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Right panel (Clinical Indications & Adverse Effects) : Clinically, imipramine is used for major depressive disorder and off-label for conditions such as neuropathic pain, panic disorder, ADHD, and treatment-resistant depression

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In combination with its excellent bioavailability in the central nervous system, these properties have led to the compound gaining interest from the scientific community for the treatment of neurodegenerative diseases

Furthermore, ferroptosis interacts with other forms of cell death, including apoptosis, autophagy, and pyroptosis, with growing evidence of crosstalk between these processes