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PDXs closely mimic human tumors and preserve genetic and physical traits in a three-dimensional setting, but they are expensive, time-consuming, and may eventually lose their human tissue components

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It undergoes enzymatic processing from its preproglucagon peptide precursor within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and peptide variants including GLP-1(7-36)

Consequently, DTP cells are phenotypic heterogeneity and challenging to define

Embo j 19:306314 Bubenik JL, Miniard AC, Driscoll DM (2014) Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2