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Several factors have been identified related to the pathogenesis of ALS: OS, mitochondrial dysfunction, neuroinflammation, excitotoxicity due to an increase in the neurotransmitter glutamate, defect in axonal transmission and in the metabolism of RNA, apoptosis, cytoskeletal abnormalities, disruption of membrane trafficking, endoplasmic reticulum stress, protein misfolding and aggregation (Papadimitriou et al., 2010

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, 2006), and in cultured rat vascular smooth muscle cells

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This migration appeared more extensive in fALS mice than in wild-type littermates [121], suggesting that motor neuron degeneration (either directly or through increased inflammation) can attract cells from the outside (Table 2)