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Abstract Homocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins

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Microglial pro-inflammatory polarization is further sustained by dysregulated potassium (KCNJ2) and calcium (TRPM2) channels, creating a vicious cycle of cytokine release and immune activation

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Mechanistically, studies with animal models and patients demonstrated that acupuncture, as a non-invasive strategy for somatosensory neuron stimulation, has potential to ameliorate gastrointestinal dysmotility via directly modulating ANS activation