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Classic example with conjugation occurring after introduction of a nucleophilic site (phenol) Kamata et al Drug Metabolism Disposition 2006 Many compounds or drugs contain functional groups that can be directly conjugated and thus do notrequire Phase I metabolism to create handles (nucleophiles) for conjugation.Ciprofloxacin Propranolol BilirubinDiflunisal Acetaminophen Thyroxine (T4)Q

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doi: 10.1007/s12011-009-8542-3 18 CollaG.NardiS.CardarelliM.ErtaniA.LuciniL.CanaguierR.et al

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Three biological replicates were prepared for each sample and each sample was measured once