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Semax/Selank Mechanism: Semax/Selank modulate neurotransmission (dopaminergic/serotonergic) and anxiolysis/neuroprotection

Decreased hydration, reduced proteoglycan content, loss of disc height, annular fissuring, and ingrowth of nerve and blood vessels (Fujii et al., 2019) are observed in degenerating discs

"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin." Nature immunology 15.5 (2014): 423-430

Klotz, J

TB-500 is based on a part of TB4, so it should, in theory, have a similar safety profile, but studies specifically analyzing its safety still need to be conducted

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