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Acknowledgements This work was supported by the Russian Science Foundation grants 19-74-30007 (A.A.M.) and 17-74-30030 (A.M., S.E., O.K.)

Taking L-carnitine by itself does not appear to reduce body weight in overweight or obese people

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Plasma TMAO, and total carnitine (TC) levels were measured by the liquid chromatography-mass spectrometry system at the Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences (Warsaw, Poland) as described previously [18, 19]