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Notably, a single intravenous administration (0.5 mg/kg) of -Gal A mRNA into Fabry mice achieved long-lasting (at least 12 weeks) attenuation of Gb3 accumulation in tissues, suggesting that less frequent dosing of mRNA therapy may be required compared to the conventional ERT therapy, which is administered biweekly [180]

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This enhanced outcome occurs because the two therapies act through different, complementary mechanisms, and together their effects produce a broader, synergistic therapeutic benefit