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This suggests that the VNS can indeed mediate the effects of gut microbiota on brain function and behavior

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.,VogelsteinB,LaneDLevineAJSurfing the p53 network.2000;408(6810):307310

It is also important to note that several other proteins (CRIF1 and SIAH2) have also been shown to directly bind NRF2 and promote its ubiquitylation (17,18), although the extent to which these interactors are involved across relative (patho)physiological contexts, as well as identification of the E3 ligase responsible for degradation, requires further investigation